Biblioteca de Filip

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Science

A collection of 4 issues

PRO, PROMs, PREMs and PPI

📢PRO: Patient-reported outcomes PROMs: Patient-reported measures PREMs: Patient-reported experiences PPI: Patient and public involvement initiative (for including patients in the research processes) Patient-Reported Measures (PROMs) PROMs are questionnaires used to measure a patient's health status and health-related quality of life. They can be either general or disease-specific and

Genotype imputation: a simple yet powerful method to infer the missing genome

Following progress, efficiency, and decreased computational cost encompassed by Moore's law, whole-genome sequencing (WGS) and whole-exome sequencing (WES) are becoming increasingly more accessible to research and industry applications but their price, which is still in the thousands of dollars, prevents massive adoption. However, because a very large proportion

CAR-T: Using biotechnology to reengineer our immune systems

Autologous chimeric antigen receptor T-cell therapy or CAR-T cell therapy in short is a type of cancer treatment in which we try to extract the T cells from a person's blood, and reengineer them by adding a novel gene that codes for a chimeric antigen receptor to match

How to (correctly) leverage Bayes' theorem in clinical practice

Imagine yourself as a family medicine physician in a regular outpatient clinic when a man walks in complaining of a headache. Now even if you know virtually nothing about medicine, two options should sound familiar - tension headache and migraine. Tension headache is a type of headache where pain radiates